Douglas A. Lauffenburger

Publication Activity (10 Years)

Years Active: 1994-2024
Publications (10 Years): 3

Top Topics

Mathematical Tools

High Throughput

Specific Problems

Top Venues

PLoS Comput. Biol.

Publications

Douglas A. Lauffenburger, Heinz Koeppl
New biological solutions to the many problems of our time. Autom. 72 (7) (2024)
Douglas K. Brubaker, Elizabeth A. Proctor, Kevin M. Haigis, Douglas A. Lauffenburger
Computational translation of genomic responses from experimental model systems to humans. PLoS Comput. Biol. 15 (1) (2019)
Wen-Han Yu, Peng Zhao, Monia Draghi, Claudia Arevalo, Christina B. Karsten, Todd J. Suscovich, Bronwyn Gunn, Hendrik Streeck, Abraham L. Brass, Michael Tiemeyer, Michael S. Seaman, John R. Mascola, Lance Wells, Douglas A. Lauffenburger, Galit Alter
Exploiting glycan topography for computational design of Env glycoprotein antigenicity. PLoS Comput. Biol. 14 (4) (2018)
Shao-Shan Carol Huang, David C. Clarke, Sara J. C. Gosline, Adam Labadorf, Candace R. Chouinard, William Gordon, Douglas A. Lauffenburger, Ernest Fraenkel
Linking Proteomic and Transcriptional Data through the Interactome and Epigenome Reveals a Map of Oncogene-induced Signaling. PLoS Comput. Biol. 9 (2) (2013)
Ioannis N. Melas, Douglas A. Lauffenburger, Leonidas G. Alexopoulos
Identification of signaling pathways related to drug efficacy in hepatocellular carcinoma via integration of phosphoproteomic, genomic and clinical data. BIBE (2013)
Daniel C. Kirouac, Julio Saez-Rodriguez, Jennifer Swantek, John M. Burke, Douglas A. Lauffenburger, Peter K. Sorger
Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks. BMC Syst. Biol. 6 (2012)
Camille Terfve, Thomas Cokelaer, David Henriques, Aidan MacNamara, Emanuel J. V. Gonçalves, Melody K. Morris, Martijn P. van Iersel, Douglas A. Lauffenburger, Julio Saez-Rodriguez
CellNOptR: a flexible toolkit to train protein signaling networks to data using multiple logic formalisms. BMC Syst. Biol. 6 (2012)
Miles Miller, Marc Hafner, Eduardo D. Sontag, Noah Davidsohn, Sairam Subramanian, Priscilla E. M. Purnick, Douglas A. Lauffenburger, Ron Weiss
Modular Design of Artificial Tissue Homeostasis: Robust Control through Synthetic Cellular Heterogeneity. PLoS Comput. Biol. 8 (7) (2012)
Melody K. Morris, Julio Saez-Rodriguez, David C. Clarke, Peter K. Sorger, Douglas A. Lauffenburger
Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli. PLoS Comput. Biol. 7 (3) (2011)
Kristen M. Naegle, Roy E. Welsch, Michael B. Yaffe, Forest M. White, Douglas A. Lauffenburger
MCAM: Multiple Clustering Analysis Methodology for Deriving Hypotheses and Insights from High-Throughput Proteomic Datasets. PLoS Comput. Biol. 7 (7) (2011)
Neda Bagheri, Marisa Shiina, Douglas A. Lauffenburger, W. Michael Korn
A Dynamical Systems Model for Combinatorial Cancer Therapy Enhances Oncolytic Adenovirus Efficacy by MEK-Inhibition. PLoS Comput. Biol. 7 (2) (2011)
Bree B. Aldridge, Julio Saez-Rodriguez, Jeremy Muhlich, Peter K. Sorger, Douglas A. Lauffenburger
Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling. PLoS Comput. Biol. 5 (4) (2009)
Karen Sachs, Solomon Itani, Jennifer Carlisle, Garry P. Nolan, Dana Pe'er, Douglas A. Lauffenburger
Learning Signaling Network Structures with Sparsely Distributed Data. J. Comput. Biol. 16 (2) (2009)
Dominik M. Wittmann, Jan Krumsiek, Julio Saez-Rodriguez, Douglas A. Lauffenburger, Steffen Klamt, Fabian J. Theis
Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling. BMC Syst. Biol. 3 (2009)
Julio Saez-Rodriguez, Arthur Goldsipe, Jeremy Muhlich, Leonidas G. Alexopoulos, Bjorn Millard, Douglas A. Lauffenburger, Peter K. Sorger
. Bioinform. 24 (6) (2008)
Leonidas G. Alexopoulos, Douglas A. Lauffenburger, Peter K. Sorger
Modeling pro-death signaling pathways in cancer hepatocytes using multi-combinatorial treatments of inhibitors and stimuli. BIBE (2008)
Neil Kumar, Alejandro Wolf-Yadlin, Forest M. White, Douglas A. Lauffenburger
Modeling HER2 Effects on Cell Behavior from Mass Spectrometry Phosphotyrosine Data. PLoS Comput. Biol. 3 (1) (2007)
Sourabh Kharait, Sampsa Hautaniemi, Shan Wu, Akihiro Iwabu, Douglas A. Lauffenburger, Alan Wells
Decision tree modeling predicts effects of inhibiting contractility signaling on cell motility. BMC Syst. Biol. 1 (2007)
Sampsa Hautaniemi, Sourabh Kharait, Akihiro Iwabu, Alan Wells, Douglas A. Lauffenburger
Modeling of signal-response cascades using decision tree analysis. Bioinform. 21 (9) (2005)
Peter J. Woolf, Wendy Prudhomme, Laurence Daheron, George Q. Daley, Douglas A. Lauffenburger
Bayesian analysis of signaling networks governing embryonic stem cell fate decisions. Bioinform. 21 (6) (2005)
Karen Sachs, Omar D. Perez, Dana Pe'er, Garry P. Nolan, David K. Gifford, Tommi S. Jaakkola, Douglas A. Lauffenburger
Analysis of Signaling Pathways in Human T-Cells Using Bayesian Network Modeling of Single Cell Data. CSB (2004)
Kevin A. Janes, Jason R. Kelly, Suzanne Gaudet, John G. Albeck, Peter K. Sorger, Douglas A. Lauffenburger
Cue-Signal-Response Analysis of TNF-Induced Apoptosis by Partial Least Squares Regression of Dynamic Multivariate Data. J. Comput. Biol. 11 (4) (2004)
Maya R. Said, Alan V. Oppenheim, Douglas A. Lauffenburger
Modeling cellular signal processing using interacting Markov chains. ICASSP (6) (2003)
Kimberly E. Forsten, Douglas A. Lauffenburger
Probability of Autocrine Ligand Capture by Cell-Surface Receptors: Implications for Ligand Secretion Measurements. J. Comput. Biol. 1 (1) (1994)