Enhancing breakpoint resolution with deep segmentation model: A general refinement method for read-depth based structural variant callers.
Yao-Zhong ZhangSeiya ImotoSatoru MiyanoRui YamaguchiPublished in: PLoS Comput. Biol. (2021)
Keyphrases
- statistical model
- segmentation method
- piece wise
- prior information
- cost function
- evaluation method
- objective function
- mathematical model
- energy function
- optimization method
- linear model
- fully automatic
- final result
- theoretical analysis
- segmentation accuracy
- input data
- probabilistic model
- prior knowledge
- bp neural network
- modeling method
- test data
- segmentation algorithm
- global shape
- pairwise
- similarity measure
- grey level
- refinement process
- neural network
- gaussian distribution
- image processing
- autoregressive
- shape prior
- shape model
- parameter estimation
- em algorithm
- piecewise constant
- graph cuts
- bayesian information criterion
- edge detection