Statistical Modeling of Transcription Factor Binding Affinities Predicts Regulatory Interactions.
Thomas MankeHelge G. RoiderMartin VingronPublished in: PLoS Comput. Biol. (2008)
Keyphrases
- statistical modeling
- dna binding
- transcription factors
- binding sites
- transcriptional regulation
- statistical models
- genome wide
- gene expression
- microarray
- chip seq
- dna sequences
- component analysis
- high throughput
- computational biology
- systems biology
- gene regulation
- transcription factor binding sites
- biological processes
- cis regulatory
- co occurrence
- regulatory networks
- protein interaction
- pairwise
- motif discovery
- biomedical literature
- cell cycle
- regulatory elements
- mixture model
- gene ontology
- feature selection
- biological networks
- statistical model
- roc curve
- microarray data