Complex-disease networks of trait-associated single-nucleotide polymorphisms (SNPs) unveiled by information theory.
Haiquan LiYounghee LeeJames L. ChenEllen RebmanJianrong LiYves A. LussierPublished in: J. Am. Medical Informatics Assoc. (2012)
Keyphrases
- information theory
- single nucleotide polymorphisms
- complex diseases
- association studies
- information theoretic
- genome wide
- high throughput
- dna sequences
- human genome
- genome wide association studies
- gene gene interactions
- computational approaches
- haplotype inference
- statistical methods
- highly correlated
- conditional entropy
- variable selection
- linkage disequilibrium
- statistical tests
- biological data
- mutual information
- genetic variation
- genomic data
- network structure
- pairwise
- data sets
- genotype phenotype
- copy number
- transcription factors
- sequence data
- support vector machine
- data mining