Predicting Protein Ligand Binding Sites by Combining Evolutionary Sequence Conservation and 3D Structure.
John A. CapraRoman A. LaskowskiJanet M. ThorntonMona SinghThomas A. FunkhouserPublished in: PLoS Comput. Biol. (2009)
Keyphrases
- protein protein
- binding sites
- predicting protein
- protein protein interactions
- protein interaction
- sequence alignment
- biological sequences
- gene expression
- sequence data
- computational methods
- secondary structure
- high throughput
- transcription factor binding sites
- molecular biology
- protein function
- data mining
- interaction networks
- dna sequences
- transcription factors
- protein sequences
- protein complexes
- structural properties
- statistical significance
- protein structure
- biological data