A Sequence-Based Dynamic Ensemble Learning System for Protein Ligand-Binding Site Prediction.
Peng ChenShanShan HuJun ZhangXin GaoJinyan LiJunfeng XiaBing WangPublished in: IEEE ACM Trans. Comput. Biol. Bioinform. (2016)
Keyphrases
- ensemble learning
- virtual screening
- binding sites
- protein protein
- sequence alignment
- protein interaction
- drug design
- predicting protein
- transcription factor binding sites
- ensemble methods
- protein families
- drug discovery
- protein protein interactions
- similarity searching
- prediction accuracy
- generalization ability
- computational methods
- gene expression
- protein structure prediction
- sequence data
- regulatory elements
- interaction networks
- protein sequences
- transcription factors
- dna sequences
- base classifiers
- high throughput
- protein function
- protein structure
- statistical significance
- secondary structure
- unlabeled data
- learning algorithm
- concept drift
- similarity search
- protein complexes
- biological data
- machine learning methods