Prediction of functional specificity determinants from protein sequences using log-likelihood ratios.
Jimin PeiWei CaiLisa N. KinchNick V. GrishinPublished in: Bioinform. (2006)
Keyphrases
- protein sequences
- log likelihood
- protein secondary structure
- protein classification
- protein structure prediction
- computational biology
- protein secondary structure prediction
- information theoretic
- maximum likelihood
- density estimation
- multiple sequence alignments
- amino acids
- em algorithm
- experimentally determined
- protein families
- protein structure
- secondary structure
- relative entropy
- scoring function
- prediction accuracy
- protein function
- sequence analysis
- amino acid sequences
- closed form
- multiple sequence alignment
- multiple alignment
- machine learning
- remote homology detection
- string kernels
- physicochemical properties
- training data