Most of the tight positional conservation of transcription factor binding sites near the transcription start site reflects their co-localization within regulatory modules.
Natalia Acevedo-LunaLeonardo Mariño-RamírezArmand HalbertUlla HansenDavid LandsmanJohn L. SpougePublished in: BMC Bioinform. (2016)
Keyphrases
- transcription factor binding sites
- cis regulatory
- transcription factors
- binding sites
- gene regulatory
- dna sequences
- regulatory elements
- microarray
- lower bound
- gene expression
- genome wide
- gene regulation
- dna binding
- component analysis
- upper bound
- worst case
- sequence data
- human genome
- co occurrence
- biomedical literature
- knowledge discovery
- motif discovery
- high throughput
- computational biology
- biological data
- gene expression data