An Evolutionary Trade-Off between Protein Turnover Rate and Protein Aggregation Favors a Higher Aggregation Propensity in Fast Degrading Proteins.
Greet De BaetsJoke ReumersJavier Delgado BlancoJoaquín DopazoJoost SchymkowitzFrederic RousseauPublished in: PLoS Comput. Biol. (2011)
Keyphrases
- amino acids
- protein sequences
- protein structure
- protein function
- trade off
- subcellular localization
- protein structure prediction
- amino acid sequences
- protein interaction data
- protein protein interactions
- protein folding
- contact map
- drug design
- tertiary structure
- predicting protein
- dna binding
- secondary structure
- protein protein interaction networks
- protein interaction
- protein secondary structure
- mass spectrometry
- protein functional
- contact maps
- protein interaction networks
- protein secondary structure prediction
- physicochemical properties
- amino acid composition
- sequence analysis
- computational biology
- physico chemical
- sequence similarity
- protein structure alignment
- functional modules
- protein complexes
- multiple sequence alignment
- chemical compounds
- computational approaches
- protein families
- multiple sequence alignments
- protein function prediction
- molecular biology
- protein protein
- protein structural
- interaction networks
- protein classification
- sequence databases
- drug discovery
- gene ontology