Li Xie

Publication Activity (10 Years)

Years Active: 2009-2023
Publications (10 Years): 2

Top Topics

Complex Diseases

High Throughput

Gene Function Prediction

Top Venues

PLoS Comput. Biol.

Publications

Li Xie, Lei Xie
Elucidation of genome-wide understudied proteins targeted by PROTAC-induced degradation using interpretable machine learning. PLoS Comput. Biol. 19 (8) (2023)
Tian Cai, Li Xie, Muge Chen, Yang Liu, Di He, Shuo Zhang, Cameron Mura, Philip E. Bourne, Lei Xie
Exploration of Dark Chemical Genomics Space via Portal Learning: Applied to Targeting the Undruggable Genome and COVID-19 Anti-Infective Polypharmacology. CoRR (2021)
Lei Xie, Xiaoxia Ge, Hepan Tan, Li Xie, Yinliang Zhang, Thomas Hart, Xiaowei Yang, Philip E. Bourne
Towards Structural Systems Pharmacology to Study Complex Diseases and Personalized Medicine. PLoS Comput. Biol. 10 (5) (2014)
Thomas Evangelidis, Philip E. Bourne, Li Xie, Lei Xie
An integrated workflow for proteome-wide off-target identification and polypharmacology drug design. BIBM Workshops (2012)
Li Xie, Thomas Evangelidis, Lei Xie, Philip E. Bourne
Drug Discovery Using Chemical Systems Biology: Weak Inhibition of Multiple Kinases May Contribute to the Anti-Cancer Effect of Nelfinavir. PLoS Comput. Biol. 7 (4) (2011)
Sarah L. Kinnings, Li Xie, Kingston H. Fung, Richard M. Jackson, Lei Xie, Philip E. Bourne
Drugome and Its Polypharmacological Implications. PLoS Comput. Biol. 6 (11) (2010)
Roger L. Chang, Li Xie, Lei Xie, Philip E. Bourne, Bernhard Ø. Palsson
Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model. PLoS Comput. Biol. 6 (9) (2010)
Li Xie, Jerry Li, Lei Xie, Philip E. Bourne
Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network To Explain the Side Effects of CETP Inhibitors. PLoS Comput. Biol. 5 (5) (2009)
Lei Xie, Li Xie, Philip E. Bourne
A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery. Bioinform. 25 (12) (2009)