Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network To Explain the Side Effects of CETP Inhibitors.
Li XieJerry LiLei XiePhilip E. BournePublished in: PLoS Comput. Biol. (2009)
Keyphrases
- drug discovery
- systems biology
- interaction networks
- virtual screening
- high throughput
- mass spectrometry
- protein protein interactions
- chemical compounds
- biological systems
- drug design
- biological networks
- biological data
- protein interaction
- molecular biology
- network model
- complex networks
- gene regulatory networks
- link prediction
- early stage
- computational biology
- protein complexes
- microarray
- network structure
- life sciences
- regulatory networks
- computational methods
- wireless sensor networks
- machine learning
- transcription factors
- data mining
- network topology