A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery.
Lei XieLi XiePhilip E. BournePublished in: Bioinform. (2009)
Keyphrases
- virtual screening
- statistical model
- binding sites
- similarity searching
- drug discovery
- sequence data
- statistical models
- similarity search
- biological sequences
- sequence alignment
- dna sequences
- scoring function
- transcription factors
- metric space
- statistical significance
- transcription factor binding sites
- chemical compounds
- gene expression
- machine learning
- data mining
- biological data
- high throughput