Thermodynamically constrained steady state solution space of the E. coli metabolic network.
Ronan M. T. FlemingAaron GoldenHeinz-Peter NasheuerPublished in: BMC Syst. Biol. (2007)
Keyphrases
- steady state
- solution space
- product form
- metabolic networks
- queueing networks
- markov chain
- genetic regulatory networks
- simulated annealing
- operating conditions
- search space
- metaheuristic
- explicit expressions
- optimal solution
- service times
- exhaustive search
- network model
- biological data
- genetic algorithm
- state dependent
- heavy traffic
- feedback loop
- steady states
- arrival rate
- feasible solution
- optimization problems
- queueing model
- scheduling problem
- control system
- high dimensional
- objective function