Sparse reduced-rank regression detects genetic associations with voxel-wise longitudinal phenotypes in Alzheimer's disease.
Maria VounouEva JanousováRobin WolzJason L. SteinPaul M. ThompsonDaniel RueckertGiovanni MontanaPublished in: NeuroImage (2012)
Keyphrases
- genome wide association studies
- genetic variation
- complex diseases
- sequence data
- genome wide
- gene gene interactions
- high throughput
- human genome
- sparse bayesian learning
- relevance vector machine
- biological data
- sparse regression
- biological knowledge
- high dimensional
- regression model
- canonical correlation analysis
- single nucleotide polymorphisms
- linear regression
- gaussian processes
- sparse kernel
- three dimensional
- support vector
- regularized regression
- gaussian process regression
- gene expression
- microarray
- sparse representation
- model selection
- pairwise
- association rules
- gene expression profiles
- risk factors
- dna sequences
- detection method
- linkage disequilibrium
- feature space