Prediction of protein binding sites in protein structures using hidden Markov support vector machine.
Bin LiuXiaolong WangLei LinBuzhou TangQiwen DongXuan WangPublished in: BMC Bioinform. (2009)
Keyphrases
- protein structure
- protein protein
- binding sites
- contact map
- experimentally determined
- protein tertiary structure
- support vector machine
- contact maps
- protein structure prediction
- protein function
- protein sequences
- physico chemical
- protein interaction
- sequence alignment
- protein families
- protein protein interactions
- molecular biology
- amino acid sequences
- predicting protein
- gene expression
- amino acids
- biological sequences
- protein structure alignment
- secondary structure
- sequence data
- protein classification
- dna sequences
- computational methods
- transcription factors
- dna binding
- motif discovery
- prediction accuracy
- transcription factor binding sites
- feature selection
- drug design
- computational biology
- computational approaches
- protein folding
- statistical significance
- tertiary structure
- coarse grained
- interaction networks