Characterizing and explaining the impact of disease-associated mutations in proteins without known structures or structural homologs.
Neeladri SenIvan AnishchenkoNicola BordinIan SillitoeSameer VelankarDavid BakerChristine A. OrengoPublished in: Briefings Bioinform. (2022)
Keyphrases
- experimentally determined
- disease genes
- structural features
- structural analysis
- secondary structure
- chemical compounds
- protein structure
- protein protein interaction networks
- computational methods
- structural information
- sequence similarity
- structural similarities
- structural models
- protein sequences
- protein protein interactions
- structural motifs
- rna sequences
- amino acid sequences
- protein structure prediction
- amino acids
- living cells
- drug design
- subcellular localization
- biological entities