Alignment-free metal ion-binding site prediction from protein sequence through pretrained language model and multi-task learning.
Qianmu YuanSheng ChenYu WangHuiying ZhaoYuedong YangPublished in: Briefings Bioinform. (2022)
Keyphrases
- language model
- multi task learning
- protein sequences
- protein protein
- binding sites
- multi task
- protein structure prediction
- computational biology
- prediction accuracy
- protein interaction
- protein structure
- learning tasks
- probabilistic model
- protein protein interactions
- gaussian processes
- protein function
- transcription factors
- information retrieval
- computational methods
- context sensitive
- secondary structure
- dna sequences
- transfer learning
- gene expression
- amino acids
- high throughput
- mixture model
- statistical significance
- amino acid sequences
- reinforcement learning
- sequence data
- pairwise