Mutations in transmembrane proteins: diseases, evolutionary insights, prediction and comparison with globular proteins.
Jan ZauchaMichael HeinzingerA. KulandaisamyEvans KatakaÓscar Llorian SalvádorPetr PopovBurkhard RostM. Michael GromihaBoris S. ZhorovDmitrij FrishmanPublished in: Briefings Bioinform. (2021)
Keyphrases
- protein sequences
- protein structure prediction
- amino acids
- subcellular localization
- amino acid residues
- protein secondary structure
- protein function
- multiple sequence alignments
- protein structure
- protein homology
- amino acid sequences
- drug design
- predicting protein
- computational biology
- protein classification
- contact map
- protein protein interactions
- multiple sequence alignment
- contact maps
- coarse grained
- protein interaction
- protein function prediction
- experimentally determined
- protein secondary structure prediction
- prediction accuracy
- secondary structure
- genetic algorithm
- physicochemical properties
- sequence analysis
- phylogenetic trees
- evolutionary process
- functional modules
- psi blast
- biological entities
- protein tertiary structure
- sequence similarity
- protein interaction data
- biological processes
- hiv protease
- molecular biology
- computational methods
- network topology
- evolutionary computation