In Silico Discrimination of Single Nucleotide Polymorphisms and Pathological Mutations in Human Gene Promoter Regions by Means of Local DNA Sequence Context and Regularity.
Imtiaz A. KhanMatthew E. MortPaul R. BucklandMichael C. O'DonovanDavid N. CooperNadia A. ChuzhanovaPublished in: Silico Biol. (2006)
Keyphrases
- single nucleotide polymorphisms
- dna sequences
- transcription factor binding sites
- coding regions
- human genome
- binding sites
- nucleotide sequences
- protein coding regions
- transcription factors
- gene structure prediction
- genome wide
- complex diseases
- genomic sequences
- high throughput
- gene prediction
- computational approaches
- rna sequences
- motif discovery
- feature selection
- biological data
- regulatory elements
- association studies
- gene expression
- statistical analysis