Why Do Hubs in the Yeast Protein Interaction Network Tend To Be Essential: Reexamining the Connection between the Network Topology and Essentiality.
Elena ZotenkoJulián MestreDianne P. O'LearyTeresa M. PrzytyckaPublished in: PLoS Comput. Biol. (2008)
Keyphrases
- essential proteins
- protein interaction networks
- protein protein interactions
- network topology
- protein complexes
- functional modules
- protein interaction data
- biological networks
- protein interaction
- protein function
- complex networks
- saccharomyces cerevisiae
- drug design
- biological processes
- high throughput
- network structure
- biomedical literature
- genomic data
- ad hoc networks
- gene ontology
- computational approaches
- routing protocol
- signaling pathways
- maximal cliques
- biological data
- clustering coefficient
- minimum spanning tree
- protein protein interaction networks
- graph theory
- real time
- cell cycle
- computational methods
- gene regulatory networks