Characterizing Genetic Interactions in Human Disease Association Studies Using Statistical Epistasis Networks.
Ting HuNicholas A. Sinnott-ArmstrongJeff KiralisAngeline S. AndrewMargaret R. KaragasJason H. MoorePublished in: BMC Bioinform. (2011)
Keyphrases
- gene gene interactions
- single nucleotide polymorphisms
- complex diseases
- genome wide
- association studies
- high throughput
- statistical methods
- genetic variation
- human genome
- haplotype inference
- statistical tests
- dna sequences
- genome wide association studies
- computational approaches
- statistical analysis
- variable selection
- sequence data
- statistical models
- decision trees
- social networks
- linkage disequilibrium
- computational methods
- information theoretic
- genetic algorithm
- genomic data
- highly correlated
- complex networks
- network structure
- search space
- pairwise
- machine learning