A2Sign: Agnostic Algorithms for Signatures - a universal method for identifying molecular signatures from transcriptomic datasets prior to cell-type deconvolution.
Galina BoldinaPaul FogelCorinne RocherCharles BettembourgGeorge LutaFranck AugéPublished in: Bioinform. (2022)
Keyphrases
- computationally efficient
- prior knowledge
- significant improvement
- theoretical analysis
- synthetic and real datasets
- computational cost
- computational efficiency
- dynamic programming
- pairwise
- preprocessing
- computational complexity
- objective function
- prior information
- segmentation algorithm
- statistical methods
- segmentation method
- sampling methods
- decision tree algorithms
- blood cells
- optimization problems
- combinatorial optimization
- clustering method
- learning algorithm
- edge detection
- support vector machine
- similarity measure
- three dimensional