RECOVER: sequential model optimization platform for combination drug repurposing identifies novel synergistic compounds in vitro.
Paul BertinJarrid Rector-BrooksDeepak SharmaThomas GaudeletAndrew AnighoroTorsten GrossFrancisco Martinez-PenaEileen L. TangSuraj M. SCristian RegepJeremy B. R. HayterMaksym KorablyovNicholas ValianteAlmer van der SlootMike TyersCharles RobertsMichael M. BronsteinLuke L. LairsonJake P. Taylor-KingYoshua BengioPublished in: CoRR (2022)
Keyphrases
- optimization model
- experimental data
- computational model
- management system
- drug discovery
- optimization process
- formal model
- mathematical model
- cost function
- objective function
- high level
- probabilistic model
- em algorithm
- theoretical analysis
- parameter estimation
- process model
- prior knowledge
- statistical model
- optimization method
- simulation model
- similarity measure
- optimization procedure
- knowledge base
- neural network