Database Screening for HIV Protease Ligands: The Influence of Binding-Site Conformation and Representation on Ligand Selectivity.
Volker SchneckeLeslie A. KuhnPublished in: ISMB (1999)
Keyphrases
- binding sites
- virtual screening
- drug discovery
- gene expression
- similarity searching
- protein protein
- dna sequences
- sequence data
- transcription factors
- statistical significance
- high throughput
- hiv protease
- motif discovery
- scoring function
- coarse grained
- protein structure
- drug design
- high dimensional
- biological sequences
- microarray
- fine grained
- data management
- database systems