A Structural Systems Biology Approach for Quantifying the Systemic Consequences of Missense Mutations in Proteins.
Tammy M. K. ChengLucas GoehringLinda JefferyYu-En LuJacqueline HaylesBéla NovákPaul A. BatesPublished in: PLoS Comput. Biol. (2012)
Keyphrases
- systems biology
- protein protein interactions
- interaction networks
- biological processes
- high throughput
- signaling pathways
- protein interaction
- biological networks
- biological systems
- biochemical networks
- functional modules
- biological data
- computational biology
- computational methods
- molecular biology
- gene regulatory networks
- protein protein interaction networks
- protein function
- protein sequences
- protein complexes
- cell cycle
- sequence similarity
- protein structure
- gene regulation
- network topology
- metabolic pathways
- regulatory networks
- microarray
- protein interaction networks
- high precision
- gene expression
- structural properties
- data sets
- life sciences
- network analysis