Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements.
Omari J. BandeleXuting WangMichelle R. CampbellGary S. PittmanDouglas A. BellPublished in: Nucleic Acids Res. (2011)
Keyphrases
- single nucleotide polymorphisms
- dna sequences
- transcription factor binding sites
- regulatory elements
- genome wide
- human genome
- high throughput
- genomic sequences
- computational approaches
- transcription factors
- complex diseases
- binding sites
- statistical tests
- genetic variation
- microarray
- gene expression
- variable selection
- statistical methods
- motif discovery
- computational methods