A Novel Ensemble-Based Scoring and Search Algorithm for Protein Redesign and Its Application to Modify the Substrate Specificity of the Gramicidin Synthetase A Phenylalanine Adenylation Enzyme.
Ryan H. LilienBrian W. StevensAmy C. AndersonBruce Randall DonaldPublished in: J. Comput. Biol. (2005)
Keyphrases
- search algorithm
- amino acids
- dead end
- protein folding
- predicting protein
- protein sequences
- drug discovery
- protein structure
- ensemble methods
- secondary structure
- neural network
- protein families
- business process
- branch and bound
- random forests
- protein structure prediction
- protein function
- learning algorithm
- ensemble learning
- multiple sequence alignments
- ensemble classifier
- heuristic search
- training data
- search space
- training set
- amino acid sequences
- random forest
- scoring model
- contact map
- selection algorithm
- multiple sequence alignment
- business processes
- magnetic recording
- protein interaction data
- feature selection
- protein protein interactions