Inhibition of cMYC-MAX transcription factors hetero-dimerization with structurally engineered omoMYC to downregulate oncogenic pathways in renal carcinoma.
Wenfeng LiFarah BanoAbbas KhanDong-Qing WeiAbdulrahman AlshammariBin XuYanjing WangPublished in: Comput. Biol. Medicine (2023)
Keyphrases
- transcription factors
- signaling pathways
- differential expression
- binding sites
- gene expression
- genome wide
- microarray
- systems biology
- drug resistance
- component analysis
- dna binding
- dna sequences
- regulatory networks
- computational biology
- co occurrence
- biological processes
- high throughput
- transcription factor binding sites
- biomedical literature
- gene expression data
- gene ontology
- highly correlated
- motif discovery
- saccharomyces cerevisiae
- sequence data
- microarray data
- statistical significance
- cis regulatory
- molecular biology
- data mining
- protein protein interactions
- biological systems
- factor analysis
- structural properties
- machine learning