De novo mutational signature discovery in tumor genomes using SparseSignatures.
Avantika LalKeli LiuRobert TibshiraniArend SidowDaniele RamazzottiPublished in: PLoS Comput. Biol. (2021)
Keyphrases
- human genome
- genomic sequences
- sequence data
- motif discovery
- dna sequences
- phylogenetic analysis
- genome wide
- knowledge discovery
- sequence analysis
- scientific discovery
- discovery process
- comparative analysis
- brain tumors
- breast cancer
- tumor segmentation
- tumor detection
- signature verification
- motif finding
- rna secondary structures
- pattern discovery
- signature recognition
- cancer diagnosis
- data mining
- protein structure
- tandem mass spectra