Identification of novel EED-EZH2 PPI inhibitors using an in silico fragment mapping method.
Kensuke MisawaNoriyuki YamaotsuShuichi HironoPublished in: J. Comput. Aided Mol. Des. (2021)
Keyphrases
- preprocessing
- significant improvement
- high precision
- computational cost
- support vector machine
- structural properties
- detection method
- detection algorithm
- support vector machine svm
- high accuracy
- experimental evaluation
- cost function
- pairwise
- probabilistic model
- neural network
- dynamic programming
- edge detection
- input data
- computer simulation
- optimization algorithm
- feature extraction
- synthetic data
- genetic algorithm
- machine learning