A robust and efficient method for estimating enzyme complex abundance and metabolic flux from expression data.
Brandon E. BarkerNarayanan SadagopanYiping WangKieran SmallboneChristopher R. MyersHongwei XiJason W. LocasaleZhenglong GuPublished in: Comput. Biol. Chem. (2015)
Keyphrases
- computationally efficient
- highly efficient
- experimental evaluation
- classification accuracy
- highly accurate
- computational cost
- pairwise
- high precision
- high accuracy
- theoretical analysis
- image noise
- high efficiency
- synthetic data
- detection method
- clustering method
- optimization algorithm
- probabilistic model
- input data
- markov random field
- support vector machine
- dynamic programming
- cost function
- significant improvement
- artificial neural networks
- objective function
- decision trees
- real world