Detecting genetic risk factors for Alzheimer's disease in whole genome sequence data via Lasso screening.
Tao YangJie WangQian SunDerrek P. HibarNeda JahanshadLi LiuYalin WangLiang ZhanPaul M. ThompsonJieping YePublished in: ISBI (2015)
Keyphrases
- sequence data
- risk factors
- genetic variation
- medical practitioners
- cardiovascular disease
- genome wide association studies
- copy number
- high risk
- risk assessment
- statistical methods
- sequence classification
- single nucleotide polymorphisms
- complex diseases
- patient groups
- diabetes mellitus
- risk management
- variable selection
- binding sites
- profile hidden markov models
- feature selection
- model selection
- genetic algorithm
- human genome
- computer aided diagnosis