Structural Hole Spanner in HumanNet Identifies Disease Gene and Drug targets.
Xiangxiang ZengJiawei LinChen LinXiangrong LiuAlfonso Rodríguez-PatónPublished in: IEEE Access (2018)
Keyphrases
- disease genes
- candidate genes
- microarray
- gene function
- gene gene
- differentially expressed genes
- gene expression
- gene sets
- complex diseases
- biological entities
- dna microarray
- graph theory
- molecular level
- gene expression levels
- gene gene interactions
- escherichia coli
- structural information
- genetic variation
- drug discovery
- structural features
- disease diagnosis
- protein protein interaction networks
- gene expression profiles
- functional genomics
- drug design
- target detection
- outbreak detection
- linkage disequilibrium
- single nucleotide polymorphisms
- multiple targets