A Role for Both Conformational Selection and Induced Fit in Ligand Binding by the LAO Protein.
Daniel-Adriano SilvaGregory R. BowmanAlejandro Sosa-PeinadoXuhui HuangPublished in: PLoS Comput. Biol. (2011)
Keyphrases
- hiv protease
- protein folding
- drug design
- virtual screening
- dna binding
- drug discovery
- protein protein
- protein protein interactions
- binding sites
- high throughput
- experimentally determined
- low energy
- protein sequences
- amino acids
- protein structure
- coarse grained
- sequence analysis
- transcription factor binding sites
- molecular dynamics
- encoding schemes
- genome wide
- computational methods