DDIG-in: detecting disease-causing genetic variations due to frameshifting indels and nonsense mutations employing sequence and structural properties at nucleotide and protein levels.
Lukas FolkmanYuedong YangZhixiu LiBela StanticAbdul SattarMatthew E. MortDavid N. CooperYunlong LiuYaoqi ZhouPublished in: Bioinform. (2015)
Keyphrases
- structural properties
- sequence alignment
- protein coding regions
- amino acid residues
- genome sequences
- protein structure
- human genome
- amino acids
- dna sequences
- influenza virus
- protein protein interactions
- pairwise
- protein sequences
- sequence data
- sequence analysis
- tree width
- genetic variation
- complex diseases
- genetic algorithm
- topological properties
- coding regions
- biological knowledge
- binding sites
- network evolution
- single nucleotide polymorphisms
- rna sequences
- sequence similarity
- gene gene interactions
- sequence databases
- secondary structure
- protein families
- protein protein interaction networks
- genomic sequences
- protein structure prediction
- genome wide