PATHOME-Drug: a subpathway-based polypharmacology drug-repositioning method.
Seungyoon NamSungyoung LeeSungjin ParkJinhyuk LeeAron ParkYon Hui KimTaesung ParkPublished in: Bioinform. (2022)
Keyphrases
- experimental evaluation
- cost function
- high accuracy
- similarity measure
- high precision
- synthetic data
- clustering method
- preprocessing
- computational complexity
- machine learning
- dynamic programming
- probabilistic model
- classification method
- significant improvement
- optimization algorithm
- error rate
- main contribution
- mathematical model
- segmentation method
- multiscale
- objective function
- input data
- knn
- prior knowledge