PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations.
Joshua C. DennyMarylyn D. RitchieMelissa A. BasfordJill M. PulleyLisa BastaracheKristin Brown-GentryDeede WangDaniel R. MasysDan M. RodenDana C. CrawfordPublished in: Bioinform. (2010)
Keyphrases
- gene gene
- biological entities
- genetic variation
- microarray
- disease genes
- gene networks
- candidate genes
- biological knowledge
- gene expression
- gene function
- sequence data
- high throughput
- wide range
- dna microarray
- differentially expressed genes
- association rules
- indirect association
- genome wide association studies
- gene expression data
- protein protein interaction networks
- functional genomics
- genome wide
- gene ontology
- human genome
- molecular level
- gene selection
- genomic data
- biologically meaningful
- data sets
- related genes
- scan data
- outbreak detection
- gene clusters
- disease diagnosis
- microarray data