An Optimization-Based Framework for the Transformation of Incomplete Biological Knowledge into a Probabilistic Structure and Its Application to the Utilization of Gene/Protein Signaling Pathways in Discrete Phenotype Classification.
Mohammad Shahrokh EsfahaniEdward R. DoughertyPublished in: IEEE ACM Trans. Comput. Biol. Bioinform. (2015)
Keyphrases
- biological knowledge
- signaling pathways
- protein protein interactions
- gene expression
- biological processes
- regulatory networks
- gene expression data
- high throughput
- probabilistic model
- biological systems
- gene regulatory networks
- protein interaction networks
- life sciences
- bayesian networks
- protein function
- protein protein interaction networks
- feature selection
- data sets
- systems biology
- gene ontology
- dynamic bayesian networks
- gene expression profiles
- machine learning