Changes in regional cerebral blood flow and functional connectivity in the cholinergic pathway associated with cognitive performance in subjects with mild Alzheimer's disease after 12-week donepezil treatment.
Wenjun LiPiero AntuonoChunming XieGang ChenJennifer L. JonesB. Douglas WardMalgorzata FranczakJoseph S. GoveasShi-Jiang LiPublished in: NeuroImage (2012)
Keyphrases
- functional connectivity
- resting state
- cerebral blood flow
- functional magnetic resonance imaging
- working memory
- cognitive states
- brain regions
- human subjects
- brain activity
- human brain
- information processing
- mild cognitive impairment
- brain images
- brain connectivity
- cognitive load
- healthy subjects
- focus of attention
- computational model
- cognitive architecture
- activation detection
- pattern classification
- data analysis
- cognitive processes
- early diagnosis
- diffusion tensor imaging
- high dimensional
- correlation analysis
- magnetic resonance images
- high degree of accuracy
- ground truth
- clinical applications
- clinical trials
- computational models
- medical images