Accurate flexible refinement for atomic-level protein structure using cryo-EM density maps and deep learning.
Biao ZhangDong LiuYang ZhangHong-Bin ShenGui-Jun ZhangPublished in: Briefings Bioinform. (2022)
Keyphrases
- deep learning
- protein structure
- unsupervised learning
- molecular biology
- machine learning
- protein sequences
- protein structure prediction
- unsupervised feature learning
- expectation maximization
- high quality
- protein tertiary structure
- generative model
- high accuracy
- amino acids
- mental models
- protein function
- protein structure alignment
- conditional random fields
- higher order
- highly accurate
- computer vision
- secondary structure
- data mining
- amino acid sequences
- em algorithm
- maximum likelihood