De Novo Signaling Pathway Predictions Based on Protein-Protein Interaction, Targeted Therapy and Protein Microarray Analysis.
Derek A. RuthsJen-Te TsengLuay NakhlehPrahlad T. RamPublished in: Systems Biology and Computational Proteomics (2006)
Keyphrases
- protein protein interactions
- signaling pathways
- high throughput
- systems biology
- biological processes
- microarray
- protein interaction
- gene ontology
- computational methods
- protein interaction data
- network topology
- protein complexes
- regulatory networks
- biological data
- biomedical literature
- protein interaction networks
- network analysis
- high precision
- functional modules
- genomic data
- biological networks
- structural properties
- computational approaches
- gene expression
- ppi networks
- gene expression data
- machine learning
- statistically significant
- feature selection