Bayesian optimization with evolutionary and structure-based regularization for directed protein evolution.
Trevor S. FrisbyChristopher James LangmeadPublished in: Algorithms Mol. Biol. (2021)
Keyphrases
- optimization problems
- evolutionary computation
- global optimization
- structural properties
- evolutionary optimization
- horizontal gene transfer
- optimization algorithm
- evolution process
- natural selection
- efficient optimization
- contact map
- evolutionary robotics
- bayesian networks
- amino acids
- multiple sequence alignments
- physicochemical properties