A computational method for designing diverse linear epitopes including citrullinated peptides with desired binding affinities to intravenous immunoglobulin.
Rob PatroRaquel NorelRobert J. PrillJulio Saez-RodriguezPeter LorenzFelix SteinbeckBjoern ZiemsMitja LustrekNicola BarbariniAlessandra TiengoRiccardo BellazziHans-Jürgen ThiesenGustavo StolovitzkyCarl KingsfordPublished in: BMC Bioinform. (2016)
Keyphrases
- experimental evaluation
- synthetic data
- high precision
- preprocessing
- cost function
- detection method
- computational cost
- dynamic programming
- significant improvement
- pairwise
- probabilistic model
- support vector machine
- objective function
- segmentation method
- linear model
- classification method
- data sets
- numerical methods
- segmentation algorithm
- support vector machine svm
- input data
- high accuracy
- computational complexity
- neural network