Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood.
Sang Hong LeeJian YangM. E. GoddardPeter M. VisscherNaomi R. WrayPublished in: Bioinform. (2012)
Keyphrases
- single nucleotide polymorphisms
- complex diseases
- maximum likelihood
- human genome
- high throughput
- genome wide
- parameter estimation
- computational approaches
- dna sequences
- highly correlated
- variable selection
- genomic data
- pairwise
- biological data
- statistical tests
- association studies
- data acquisition
- microarray
- copy number
- data mining
- genome wide association studies