Predicting the phenotypic effects of non-synonymous single nucleotide polymorphisms based on support vector machines.
Jian TianNingfeng WuXuexia GuoJun GuoJuhua ZhangYunliu FanPublished in: BMC Bioinform. (2007)
Keyphrases
- single nucleotide polymorphisms
- support vector
- genotype phenotype
- high throughput
- genome wide
- human genome
- complex diseases
- low cost
- loss function
- dna sequences
- computational approaches
- cross validation
- support vector machine
- kernel function
- logistic regression
- statistical tests
- genomic data
- gene expression
- feature selection