Predicting Total Drug Clearance and Volumes of Distribution Using the Machine Learning-Mediated Multimodal Method through the Imputation of Various Nonclinical Data.
Hiroaki IwataTatsuru MatsuoHideaki MamadaTakahisa MotomuraMayumi MatsushitaTakeshi FujiwaraKazuya MaedaKoichi HandaPublished in: J. Chem. Inf. Model. (2022)
Keyphrases
- synthetic data
- missing values
- missing data
- machine learning
- statistical methods
- data distribution
- test data
- input data
- data collection
- high dimensional data
- machine learning methods
- data analysis
- prior knowledge
- data structure
- data sets
- noisy data
- data quality
- information loss
- uniformly distributed
- preprocessing
- objective function
- detection method
- model selection
- text classification
- data points
- probability distribution
- database
- knowledge discovery
- data sources
- pairwise
- similarity measure
- data mining
- bayesian methods