A Bayesian Framework to Account for Complex Non-Genetic Factors in Gene Expression Levels Greatly Increases Power in eQTL Studies.
Oliver StegleLeopold PartsRichard DurbinJohn M. WinnPublished in: PLoS Comput. Biol. (2010)
Keyphrases
- bayesian framework
- gene expression
- association studies
- genome wide association studies
- prior knowledge
- gene expression levels
- generative model
- microarray
- haplotype inference
- genome wide
- maximum a posteriori
- expectation maximization
- single nucleotide polymorphisms
- linkage disequilibrium
- binding sites
- monitoring system
- pairwise
- machine learning
- data sets