Prediction of hot spots in protein-DNA binding interfaces based on supervised isometric feature mapping and extreme gradient boosting.
Ke LiSijia ZhangDi YanYannan BinJunfeng XiaPublished in: BMC Bioinform. (2020)
Keyphrases
- dna binding
- hot spots
- protein interaction
- protein protein interactions
- binding sites
- transcription factors
- manifold learning
- gene expression
- dna sequences
- machine learning
- data mining
- structural properties
- sequence data
- semi supervised
- support vector machine
- feature selection
- learning algorithm
- text classification
- supervised learning
- nearest neighbor
- computational methods
- component analysis
- social networks
- protein families