SMURFLite: combining simplified Markov random fields with simulated evolution improves remote homology detection for beta-structural proteins into the twilight zone.
Noah M. DanielsRaghavendra HosurBonnie BergerLenore J. CowenPublished in: Bioinform. (2012)
Keyphrases
- markov random field
- protein sequences
- protein classification
- remote homology detection
- graph cuts
- belief propagation
- random fields
- parameter estimation
- energy minimization
- mrf model
- higher order
- image segmentation
- energy function
- maximum a posteriori
- pairwise
- potential functions
- conditional random fields
- protein structure
- string kernels
- protein function
- amino acids
- grammatical inference
- computer vision
- piecewise constant functions
- multi class
- computational methods
- computational biology
- feature extraction