Non-linear optimization of biochemical pathways: applications to metabolic engineering and parameter estimation.
Pedro MendesDouglas B. KellPublished in: Bioinform. (1998)
Keyphrases
- parameter estimation
- metabolic engineering
- systems biology
- maximum likelihood
- high throughput
- least squares
- model selection
- statistical models
- markov random field
- em algorithm
- parameter estimation algorithm
- random fields
- biological systems
- expectation maximization
- approximate inference
- parameter estimates
- maximum likelihood estimation
- biological networks
- structure learning
- higher order
- machine learning
- signal transduction pathways
- biological data
- experimental data
- image processing
- gene regulatory networks
- computational biology
- data sources
- computer vision